High-dose thiamine and Parkinson's disease


Parkinson’s disease is a neurodegenerative disorder that affects movement, balance, and coordination. It is caused by the death of dopamine-producing neurons in the brain. There is no cure for Parkinson’s disease, but there are treatments that can help to manage the symptoms.

The Role of Thiamine in Parkinson’s Disease:

Thiamine (Vitamin B1) is a vitamin that is essential for the proper functioning of the nervous system. It is involved in the metabolism of glucose, which is the brain’s main source of energy. Some studies have suggested that low levels of thiamine may be a risk factor for Parkinson’s disease.

The Effects of High-Dose Thiamine on Parkinson’s Disease:

There have been a few small clinical trials that have investigated the effects of high-dose thiamine in Parkinson’s disease. These trials have shown that high-dose thiamine can improve motor symptoms, such as tremor and rigidity. It can also improve non-motor symptoms, such as fatigue and depression.

The Mechanism of Action of High-Dose Thiamine in Parkinson’s Disease:

The exact mechanism of action of high-dose thiamine in Parkinson’s disease is not fully understood. However, it is thought that thiamine may help to protect dopamine-producing neurons from damage. It may also help to improve the function of the mitochondria, which are the energy-producing powerhouses of the cell.

Safety of High-Dose Thiamine:

High-dose thiamine is generally considered to be safe. However, there have been some reports of side effects, such as nausea and vomiting. These side effects are usually mild and go away on their own.


High-dose thiamine is a potential treatment for Parkinson’s disease. It has been shown to improve motor and non-motor symptoms, and it is generally considered to be safe. More research is needed to confirm the findings of clinical trials, but a regimen of high-dose vitamin B1 shows promise as a new treatment for Parkinson’s disease.

Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828997/

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ByChris Apicella

As a Berkeley graduate in biochemistry, my passion for health, wellness, and anti-aging has been fueled by years of dedicated experience in these fields. Through my blog, I aim to share the wealth of knowledge and insights I've accumulated, providing valuable information and practical advice to empower others on their journey to optimal health. Join me as I navigate the ever-evolving landscape of health and supplements, offering science-backed perspectives and personal experiences to inspire positive lifestyle changes.

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